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Acenocoumarol adherence Administration adverse drug reaction antibiotics antineoplastic agents antiretroviral treatment Argentina atención farmacéutica automobile driving biological therapy cerebrospinal fluid cost-effectiveness COVID-19 Darunavir direct acting antivirals drug-related side effects and adverse reactions drug interactions drugs drug therapy elderly Failure mode effect analysis health personnel HIV hypertension interaction lupus Medication errors monoterapia monotherapy multiple myeloma nursing homes pharmaceutical services pharmaceutical validation pharmacy service rational use rational use of medicines rheumatoid arthritis risk ritonavir safety thrombocytopenia Total parenteral nutrition toxicity tratamiento antirretroviral